Department Of Cell Biology And Genetics | Palacky University | Czech Republic
Doc. Ing. Radim Vrzal, Ph.D., is an Associate Professor at the Department of Cell Biology and Genetics, Faculty of Science, Palacký University Olomouc, Czech Republic. He earned his M.Sc. in Biochemistry from the Institute of Chemical Technology in Prague (1998–2003) and completed a cotutelle Ph.D. in Medical Chemistry and Biochemistry jointly at Palacký University and INSERM U632, CNRS, Montpellier, France (2003–2007). Dr. Vrzal’s research focuses on the biological activity of natural and synthetic compounds, ligand-activated nuclear receptors (AhR, AR, PXR, VDR, GR), drug metabolism, cytotoxicity, cellular signaling, and human intestinal organoid models, with a special interest in prostate cancer. He has served as corresponding author on several high-impact studies, including recent works in Biochimie, Nature Communications, and International Journal of Molecular Sciences. He has led and contributed to multiple national and international grants, including projects on MAP kinase signaling and post-translational regulation of CYP3A4, and currently serves as principal investigator on cancer therapeutics research supported by the League Against Cancer Prague. Dr. Vrzal has supervised over 40 bachelor’s, master’s, and Ph.D. theses, and regularly lectures on hematology, human genetics, and toxicology. His academic contributions and mentorship have significantly advanced understanding of xenobiotic receptor signaling and its implications for pharmacotherapy and oncology. He has authored 87 publications indexed in Web of Science, accumulating over 2,147 citations with an H-index of 28.
Publications
1. Vrzal, R., Grycová, A., & Vrzalová, A. (2025). Skin-targeted AhR activation by microbial and synthetic indoles: Insights from the AhaRaCaT reporter cell line. Toxicology Letters.
2. Vrzalová, A., & Vrzal, R. (2025). Orchestra of ligand-activated transcription factors in the molecular symphony of SERPINE 1 / PAI-1 gene regulation. Biochimie.
3. Vrzalová, A., Vrzal, R., Nádvorník, P., Šebela, M., & Dvořák, Z. (2024). Modulation of aryl hydrocarbon receptor activity by halogenated indoles. Bioorganic and Medicinal Chemistry.
4. Vrzal, R., Marcalíková, A., Krasulová, K., Zemánková, L., & Dvořák, Z. (2023). Jasmone is a ligand-selective allosteric antagonist of aryl hydrocarbon receptor (AhR). International Journal of Molecular Sciences.
5. Ondrová, K., Zůvalová, I., Vyhlídalová, B., Krasulová, K., Miková, E., Vrzal, R., Nádvorník, P., Kopečná, M., Kopečný, D., Šebela, M., et al. (2023). Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice. Nature Communications.